In vitro cytotoxicity of arnica brasileira (Solidago microglossa) and arnica paulista (Porophyllum ruderale)

Authors

  • Manoela Domingues Martins UNINOVE
  • Marcia Martins Marques Faculdade de Odontologia da USP
  • Sandra Kalil Bussadori UNINOVE
  • Raquel Agneli Mesquita-Ferrari UNINOVE
  • Vanessa Christina Santos Pavesi Uninove
  • Nilsa Sumie Wadt UNINOVE
  • Kristianne Porta Fernandes UNINOVE

DOI:

https://doi.org/10.5585/conssaude.v8i1.1457

Keywords:

Arnica brasileira, Arnica paulista, Porophyllum ruderale, Solidago microglossa, Teste de materiais, Viabilidade celular.

Abstract

Arnica is a phytotherapeutic extensively used in clinical medicine, which has analgesic, anti-inflammatory and cicatrizant effects. It is used in tincture form or in topical treatment of contusions, hematomas, stretching, swelling and injuries in general. Our objective is to evaluate the cytotoxicity of the extract of arnica brasileira (Solidago microglossa) and arnica paulista (Porophyllum ruderale) in excipient for use in oral ulcers on fibroblasts of human buccal mucosa (FMM1) cultivated. The FMM1 were kept for 24h in contact with the conditioned environment with arnica paulista and brasileira. The analysis of cytotoxicity was performed by the method of MTT. The results were compared by ANOVA method complemented by the Tukey test considering p ≤ 0.05. The substances analyzed were considered biocompatible, presenting mitochondrial activity similar to the control. We conclude that the extracts are biocompatible in vitro with fibroblasts of human oral mucosa and should be tested in vivo to examine its anti-inflammatory and healing action.

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Author Biographies

Manoela Domingues Martins, UNINOVE

Professora do Programa de Mestrado em Ciências da Reabilitação- UNINOVE

Marcia Martins Marques, Faculdade de Odontologia da USP

Professora do Departamento de Dentística da Faculdade de Odontologia da USP

Sandra Kalil Bussadori, UNINOVE

Professora do Programa de Mestrado em Ciências da Reabilitação- UNINOVE

Raquel Agneli Mesquita-Ferrari, UNINOVE

Professora do Programa de Mestrado em Ciências da Reabilitação- UNINOVE

Vanessa Christina Santos Pavesi, Uninove

Aluna do Programa de Mestrado em Ciencias da Reabilitação- UNINOVE

Nilsa Sumie Wadt, UNINOVE

Professora da Diretoria da Saúde - UNINOVE

Kristianne Porta Fernandes, UNINOVE

Professora do Programa de Mestrado em Ciências da Reabilitação- UNINOVE

Published

2009-05-11

How to Cite

1.
Martins MD, Marques MM, Bussadori SK, Mesquita-Ferrari RA, Pavesi VCS, Wadt NS, et al. In vitro cytotoxicity of arnica brasileira (Solidago microglossa) and arnica paulista (Porophyllum ruderale). Cons. Saúde [Internet]. 2009 May 11 [cited 2024 Jul. 17];8(1):99-104. Available from: https://periodicos.uninove.br/saude/article/view/1457

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Section

Artigos