Ulcerogenic activity of celecoxib, piroxicam and piroxicam associated with zinc sulfate in granuloma model in rats

Authors

  • Janaina do Amaral Bueno
  • Raphael Fernando Boiati UNINOVE
  • Fabiana Gatti de Menezes Uninove
  • Jorge Willian Leandro Nascimento UNINOVE, SP

DOI:

https://doi.org/10.5585/conssaude.v9i1.2059

Keywords:

Antiinflamatórios não esteróides, Celecoxibe, Piroxicam, Úlcera, Zinco.

Abstract

OBJECTIVES: The aim of this study was to evaluate the ulcerogenic activity of celecoxib (selective COX-2), the piroxicam and piroxicam + zinc sulfate (nonselective NSAIDs). METHOD: It has been utilized introduction of cotton pellets in the abdominal region of rats, and by evaluating the formation of gastric lesions promoted by the model. RESULTS: The results showed that granuloma formation did not induce gastric lesions. CONCLUSIONS: Among the drugs studied, there was a higher incidence of gastric lesions caused by piroxicam when compared with celecoxib, while the association piroxicam + zinc sulfate had lower gastric lesion, when compared to piroxicam.

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Author Biography

Jorge Willian Leandro Nascimento, UNINOVE, SP

Mestre em Ciências Farmacêuticas (UFMG) Doutor em Farmaco e medicamentos (USP)

Published

2010-06-17

How to Cite

1.
Bueno J do A, Boiati RF, de Menezes FG, Nascimento JWL. Ulcerogenic activity of celecoxib, piroxicam and piroxicam associated with zinc sulfate in granuloma model in rats. Cons. Saúde [Internet]. 2010 Jun. 17 [cited 2024 May 19];9(1):79-86. Available from: https://periodicos.uninove.br/saude/article/view/2059

Issue

Section

Applied Sciences