IL-10 gene polymorphism in elderly with periodontal disease

Abstract

Introduction: Genetic factors contribute to the risk of periodontal disease (PD) in the elderly. Objective: This study aimed to evaluate the association between periodontal disease and interleukin-10 gene polymorphism in 66 elderly. Methods: PD was diagnosed using the index PIP. The genetic polymorphism was analyzed by polymerase chain reaction followed by cleavage with restriction enzyme Rsa I. Results: The study included 66 elderly (mean age: 68 ± 5.02 years), 63.3% female gender and 36.4% male. The elderly harboring AA genotype or A allele were significantly associated with severe PD, according to 2 test (p<0.05), suggesting that this genotype or allele may be a genetic factor leading to chronic susceptibility of PD. Conclusions: The genetic polymorphism at position -627 of the IL-10 gene may influence the PD severity in the elderly.