Dissociation of the polymorphism of angiotensin-converting enzyme with strength, and muscle volume and quality in sedentary women

Abstract

Introduction: Strength and muscle mass reflect the interactions between environmental factors and genetics. Objective: To analyze the influence of the genotype of the angiotensin converting enzyme (ACE) on strength, muscle volume, quality and total-body skeletal muscle mass in middle-aged sedentary women. Methods: The sample consisted of 32 women divided into two groups according to the I/D polymorphism that underwent assessments of muscular strength tests of 1RM. In addition muscle volume measurements of the quadriceps and biceps by ultrasound were obtained, and the muscle quality of the biceps and quadriceps. Results: There was no difference on muscle strength, volume and quality neither of the quadriceps and biceps muscles, nor in the total-body skeletal muscle mass. Conclusions: The findings of this study did not demonstrate an important role of the polymorphism in the ACE gene in determining the phenotypes of strength, muscle volume and quality of middle-aged sedentary women.