Biotrauma: a pathophysiologic approach

Authors

  • Patrícia Tamami Sasaki
  • Renato Lopes de Souza UNIFESP, UNINOVE, SP

DOI:

https://doi.org/10.5585/conssaude.v7i2.683

Keywords:

Biotrauma, Lesão pulmonar, Mediadores inflamatórios, Síndrome do desconforto respiratório agudo.

Abstract

Mechanical ventilation is an important life support tool in the intensive care units; however, it can cause different types of lung injury as barotrauma, volutrauma atelectrauma and biotrauma. Biotrauma no protective ventilator strategies could induce a hyper activation of the immune system and release of inflammatory mediators leading to local and systemic lesions, causing multiple organ dysfunction. The way it happens is still unknown, but four mechanisms are being related: a) Disruption of the plasma membrane; b) Disruption in the connection of lung endothelial and epithelial cells; c) Mechanotransduction; d) Effect on pulmonary vasculature.

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Author Biographies

Patrícia Tamami Sasaki

Monografia de conclusão da residência de 3o ano em Terapia Intensiva Pediátrica-EMP/UNIFESP Rua Monsenhor Nuno de Faria Paiva 130 Mogilar Mogi das Cruzes – SP 08773-530

Renato Lopes de Souza, UNIFESP, UNINOVE, SP

Doutor em Pediatria e Ciências Aplicadas á Pediatria pela Universidade Federal de São Paulo, UNIFESP; Mestre em Pediatria e Ciências Aplicadas à Pediatria pela Universidade Federal de São Paulo, UNIFESP; Médico Assistente da UTI Pediátrica do Hospital São Paulo – EPM-UNIFESP e professor da UNINOVE.

Published

2008-11-26

How to Cite

1.
Sasaki PT, Souza RL de. Biotrauma: a pathophysiologic approach. Cons. Saúde [Internet]. 2008 Nov. 26 [cited 2024 Jul. 17];7(2):235-40. Available from: https://periodicos.uninove.br/saude/article/view/683

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Artigos