Autonomic modulation and chronotropic activity during aerobic exercise in patients using atenolol
DOI:
https://doi.org/10.5585/conscientiaesaude/2011/v10n1/2567Palavras-chave:
Atenolol, Hypertension, Pharmacokinetics.Resumo
Introduction: The negative chronotropic effect of beta-blockers (BB) can modify itself according to its pharmacokinetics. Objective: To investigate the influence of pharmacokinetics of beta-blockers in heart rate (HR) and autonomic activity (AA) in response to the exercise. Methods: Three groups of hypertensive patients, users of atenolol (n=9), enalapril, (n=8), and a normotensive control group (n=8), performed two sessions of moderate exercise on a cycloergometer, during 40 minutes, whereby 2 hours (Session I), or 23 hours after drug administration (Session II). Records of electrocardiogram were made before, during and after the exercises. Results: The HR was lower in session I comparing with session II of the atenolol group during the exercise. There were no differences in the components of low and high frequency of AA between these sessions. Conclusions: These results confirm the negative chronotropic effect of BB. However, the absence of changes in AA suggests that other mechanisms may be contributing to this phenomenon.Downloads
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31.03.2011
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Alves NFB, Porpino SKP, Brito A de F, Nóbrega TKS da, Freitas R de S, Silva AS, et al. Autonomic modulation and chronotropic activity during aerobic exercise in patients using atenolol. Cons. Saúde [Internet]. 31º de março de 2011 [citado 1º de junho de 2025];10(1):51-8. Disponível em: https://periodicos.uninove.br/saude/article/view/2567
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