Autonomic modulation and chronotropic activity during aerobic exercise in patients using atenolol

Naiane Ferraz Bandeira Alves, Suênia Karla Pacheco Porpino, Aline de Freitas Brito, Thereza Karolina Sarmento da Nóbrega, Rosimeire de Souza Freitas, Alexandre Sérgio Silva, Manoel da Cunha Costa, Guilherme Laurentino de Lima-Filho


Introduction: The negative chronotropic effect of beta-blockers (BB) can modify itself according to its pharmacokinetics. Objective: To investigate the influence of pharmacokinetics of beta-blockers in heart rate (HR) and autonomic activity (AA) in response to the exercise. Methods: Three groups of hypertensive patients, users of atenolol (n=9), enalapril, (n=8), and a normotensive control group (n=8), performed two sessions of moderate exercise on a cycloergometer, during 40 minutes, whereby 2 hours (Session I), or 23 hours after drug administration (Session II). Records of electrocardiogram were made before, during and after the exercises. Results: The HR was lower in session I comparing with session II of the atenolol group during the exercise. There were no differences in the components of low and high frequency of AA between these sessions. Conclusions: These results confirm the negative chronotropic effect of BB. However, the absence of changes in AA suggests that other mechanisms may be contributing to this phenomenon.


Atenolol; Hypertension; Pharmacokinetics.

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Conscientiae Saúde
ISSN: 1677-1028
e-ISSN: 1983-9324

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