Influence of creatine supplementation on muscle mass of rats

Authors

  • Renato Aparecido de Souza UNIVAP
  • Humberto Miranda UNIVAP
  • Rodrigo Alexis Lazo Osório UNIVAP
  • Belmiro Salles UNIVAP
  • Roberto Simão UNIVAP
  • Wellington Ribeiro UNIVAP

DOI:

https://doi.org/10.5585/conssaude.v8i2.1602

Keywords:

Músculo esquelético, Ratos, Suplementação de creatina.

Abstract

The aim of this study was to investigate the effects of the short-term (5g. kg -1 for 1 week) and long-term (1g. kg -1 for 8 weeks) creatine supplementation on ponderal adaptation of anterior tibial and soleus muscles of sedentary and exercised (swimming to 80% of the tolerated maximum load) rats.72 Wistar males rats (240 ± 10g) were divided in 4 groups: sedentary rats without supplementation (CON; n = 18); exercised rats without supplementation (NAT; n = 18); sedentary rats with supplementation (CRE; n = 18); exercised rats with supplementation (CRE+NAT; n = 18). At the end of the first, fourth and eighth weeks six animals of each group were sacrificed. There were obtained the following results (p<0.05): superior average of anterior tibial muscle absolute mass in CRE and CRE+NAT; superior average of absolute and relative soleus muscle mass in the CRE+NAT in relation to other groups after four and eight experimental weeks. These findings suggest that the creatine supplementation causes positive ponderal adaptations in skeletal muscle tissue independly of physical exercise realization.

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Author Biographies

Renato Aparecido de Souza, UNIVAP

Laboratório de Fisiologia e Farmacodinâmica (Instituto de Pesquisa e Desenvolvimento – IP&D) - Universidade do Vale do Paraíba – UNIVAP – São José dos Campos/SP, Brasil.

Humberto Miranda, UNIVAP

Laboratório de Fisiologia e Farmacodinâmica (Instituto de Pesquisa e Desenvolvimento – IP&D) - Universidade do Vale do Paraíba – UNIVAP – São José dos Campos/SP, Brasil. Cel (21) 8851-3474

Rodrigo Alexis Lazo Osório, UNIVAP

Laboratório de Fisiologia e Farmacodinâmica (Instituto de Pesquisa e Desenvolvimento – IP&D) - Universidade do Vale do Paraíba – UNIVAP – São José dos Campos/SP, Brasil.

Belmiro Salles, UNIVAP

Laboratório de Pesquisa em Microcirculação (Departamento de Ciências Fisiológicas), Universidade do Estado do Rio de Janeiro, UERJ, Rio de Janeiro/RJ, Brasil.

Roberto Simão, UNIVAP

Escola de Educação Física e Desportos – Universidade Federal do Rio de Janeiro (EEFD/UFRJ), Rio de Janeiro/RJ, Brasil.

Wellington Ribeiro, UNIVAP

Laboratório de Fisiologia e Farmacodinâmica (Instituto de Pesquisa e Desenvolvimento – IP&D) - Universidade do Vale do Paraíba – UNIVAP – São José dos Campos/SP, Brasil.

Published

2009-07-29

How to Cite

1.
Souza RA de, Miranda H, Osório RAL, Salles B, Simão R, Ribeiro W. Influence of creatine supplementation on muscle mass of rats. Cons. Saúde [Internet]. 2009 Jul. 29 [cited 2024 Jul. 17];8(2):177-82. Available from: https://periodicos.uninove.br/saude/article/view/1602

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