Association between diabetes mellitus and evolution to intubation or death for individuals hospitalized with Covid-19

Authors

DOI:

https://doi.org/10.5585/22.2023.24273

Keywords:

Covid-19, Sars-cov-2, Diabetes Mellitus, Death, Intubation

Abstract

Introduction: Patients infected with COVID-19 seem to manifest a more severe evolution when they have comorbidities, such as Diabetes Mellitus (DM). However, data on the Brazilian population are still scarcely available.
Objective: To analyze the association between DM and evolution to intubation and death in individuals hospitalized with COVID-19.
Methodology: Cross-sectional, observational, quantitative study with data from the medical records of 74 adult participants admitted to Professora Lydia Storópoli Hospital, diagnosed with COVID-19. The Human Research Ethics Committee approved this study, and participants signed the study consent form.
Results: 74 patients with Covid-19, 18 had DM, of which six evolved to intubation, and five evolved to death. There was no significant association (p>0.05) between DM and intubation and death.
Conclusion: In the present study, DM was not associated with clinical evolution to intubation and death.

CROSSMARK_Color_horizontal.svg

Downloads

Download data is not yet available.

Author Biographies

Paulo Henrique Leite Souza , Universidade Nove de Julho (UNINOVE)

Fisioterapeuta pela Universidade Nove de Julho - UNINOVE (2020), Mestre em Ciência da Reabilitação pela Universidade Nove de Julho - UNINOVE (2022).

João Carlos Ferrari Corrêa, Universidade Nove de Julho (UNINOVE)

Fisioterapeuta pela Universidade Estadual Paulista - UNESP (1995), Mestrado em Fisiologia e Biofísica pela Universidade Estadual de Campinas - UNICAMP (1999) e Doutorado em Morfologia pela Universidade Estadual de Campinas - UNICAMP (2002)

Laura Uehara, Universidade Nove de Julho (UNINOVE)

Fisioterapeuta pela Universidade Bandeirante de São Paulo (2003), Mestre em Ciências da Reabilitação pela Universidade Nove de Julho - UNINOVE (2021).

Lucas Kiyoshi Kishima, Universidade Nove de Julho (UNINOVE)

Aluno de Fisioterapia da Universidade Nove de Julho - UNINOVE

Bárbara Rany Bertolini, Universidade Nove de Julho (UNINOVE)

Aluna de Fisioterapia da Universidade Nove de Julho - UNINOVE

Wellington Segheto, Universidade Nove de Julho (UNINOVE)

Educador Físico pela Universidade Federal de Viçosa - UFV (1996), Mestrado em Educação Física pela Universidade São Judas Tadeu - USJT (2010), Doutorado em Ciência da Nutrição pela Universidade Federal de Viçosa - UFV (2015), Doutorado em Educação Física pela Universidade Federal de Viçosa - UFV (2021), Pós-doutorado em Ciência da Nutrição pela Universidade Federal de Viçosa (2016) e Pós-Doutorado em Ciências da Reabilitação pela Universidade Nove de Julho (2022).

Raphael Mendes Ritti-Dias, Universidade Nove de Julho (UNINOVE)

Educador Físico pela Universidade Estadual de Londrina - UEL (2003), Doutorado em Saúde Pública pela Universidade de São Paulo - USP (2008) com período sanduíche em University of Oklahoma.

Fernanda Ishida Corrêa, Universidade Nove de Julho (UNINOVE)

Fisioterapeuta pela Universidade Estadual Paulista Júlio de Mesquita Filho (1999), Mestrado em Engenharia Biomédica pela Universidade do Vale do Paraíba (2001) e doutorado em Engenharia Biomédica pela Universidade do Vale do Paraíba (2009). 

References

Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. A Novel Coronavirus from Patients with Pneumonia in China, 2019. New England Journal of Medicine. 2020 Feb 20;382(8):727–33.

Wiersinga WJ, Rhodes A, Cheng AC, Peacock SJ, Prescott HC. Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19). JAMA. 2020 Aug 25;324(8):782.

Huang C, Xu X, Cai Y, Ge Q, Zeng G, Li X, et al. Mining the Characteristics of COVID-19 Patients in China: Analysis of Social Media Posts. J Med Internet Res. 2020 May 17;22(5):e19087.

Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. The Lancet. 2020 Feb;395(10223):497–506.

Xu Z, Shi L, Wang Y, Zhang J, Huang L, Zhang C, et al. Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir Med. 2020 Apr;8(4):420–2.

Gasmi A, Peana M, Pivina L, Srinath S, Gasmi Benahmed A, Semenova Y, et al. Interrelations between COVID-19 and other disorders. Clinical Immunology. 2021 Mar; 224:108651.

Pranata R, Lim MA, Huang I, Raharjo SB, Lukito AA. Hypertension is associated with increased mortality and severity of disease in COVID-19 pneumonia: A systematic review, meta-analysis and meta-regression. Journal of the Renin-Angiotensin-Aldosterone System. 2020 Apr 14;21(2):147032032092689.

Ravichandran B, Grimm D, Krüger M, Kopp S, Infanger M, Wehland M. SARS‐CoV‐2 and hypertension. Physiol Rep. 2021 Jun 13;9(11).

de Almeida-Pititto B, Dualib PM, Zajdenverg L, Dantas JR, de Souza FD, Rodacki M, et al. Severity and mortality of COVID 19 in patients with diabetes, hypertension and cardiovascular disease: a meta-analysis. Diabetol Metab Syndr. 2020 Dec 31;12(1):75.

Pinto LC, Bertoluci MC. Type 2 diabetes as a major risk factor for COVID-19 severity: a meta-analysis. Arch Endocrinol Metab. 2020 Jun 5;64(3):199–200.

Huang I, Lim MA, Pranata R. Diabetes mellitus is associated with increased mortality and severity of disease in COVID-19 pneumonia – A systematic review, meta-analysis, and meta-regression. Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 2020 Jul;14(4):395–403.

Roncon L, Zuin M, Rigatelli G, Zuliani G. Diabetic patients with COVID-19 infection are at higher risk of ICU admission and poor short-term outcome. Journal of Clinical Virology. 2020 Jun;127:104354.

Kumar A, Arora A, Sharma P, Anikhindi SA, Bansal N, Singla V, et al. Is diabetes mellitus associated with mortality and severity of COVID-19? A meta-analysis. Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 2020 Jul;14(4):535–45.

Sociedade Brasileira de Diabetes. Diretrizes da Sociedade Brasileira de Diabetes 2019-2020. 2019. 1–491 p.

Oliveira MIA, Souza EM de, Pedrosa F de O, Réa RR, Alves A da SC, Picheth G, et al. RAGE receptor and its soluble isoforms in diabetes mellitus complications. J Bras Patol Med Lab. 2013 Apr;49(2):97–108.

Casqueiro J, Casqueiro J, Alves C. Infections in patients with diabetes mellitus: A review of pathogenesis. Indian J Endocrinol Metab. 2012;16(7):27.

Peleg AY, Weerarathna T, McCarthy JS, Davis TME. Common infections in diabetes: pathogenesis, management and relationship to glycaemic control. Diabetes Metab Res Rev. 2007 Jan;23(1):3–13.

Moutschen MP, Scheen AJ, Lefebvre PJ. Impaired immune responses in diabetes mellitus: analysis of the factors and mechanisms involved. Relevance to the increased susceptibility of diabetic patients to specific infections. Diabete Metab. 1992;18(3):187–201.

Rubino F, Amiel SA, Zimmet P, Alberti G, Bornstein S, Eckel RH, et al. New-Onset Diabetes in Covid-19. New England Journal of Medicine. 2020 Aug 20;383(8):789–90.

Lima-Martínez MM, Carrera Boada C, Madera-Silva MD, Marín W, Contreras M. COVID-19 y diabetes mellitus: una relación bidireccional. Clínica e Investigación en Arteriosclerosis. 2021 May;33(3):151–7.

Yang X, Yu Y, Xu J, Shu H, Xia J, Liu H, et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respir Med. 2020 May;8(5):475–81.

Yang J, Zheng Y, Gou X, Pu K, Chen Z, Guo Q, et al. Prevalence of comorbidities and its effects in patients infected with SARS-CoV-2: a systematic review and meta-analysis. International Journal of Infectious Diseases. 2020 May;94:91–5.

Garg S, Kim L, Whitaker M, O’Halloran A, Cummings C, Holstein R, et al. Hospitalization Rates and Characteristics of Patients Hospitalized with Laboratory-Confirmed Coronavirus Disease 2019 — COVID-NET, 14 States, March 1–30, 2020. MMWR Morb Mortal Wkly Rep. 2020 Apr 17;69(15):458–64.

Remuzzi A, Remuzzi G. COVID-19 and Italy: what next? The Lancet. 2020 Apr;395(10231):1225–8.

Grasselli G, Greco M, Zanella A, Albano G, Antonelli M, Bellani G, et al. Risk Factors Associated With Mortality Among Patients With COVID-19 in Intensive Care Units in Lombardy, Italy. JAMA Intern Med. 2020 Oct 1;180(10):1345.

Pal R, Bhadada SK, Misra A. COVID-19 vaccination in patients with diabetes mellitus: Current concepts, uncertainties and challenges. Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 2021 Mar;15(2):505–8.

Baden LR, El Sahly HM, Essink B, Kotloff K, Frey S, Novak R, et al. Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine. New England Journal of Medicine. 2021 Feb 4;384(5):403–16.

He YF, Ouyang J, Hu XD, Wu N, Jiang ZG, Bian N, et al. Correlation between COVID-19 vaccination and diabetes mellitus: A systematic review. World J Diabetes. 2023 Jun 15;14(6):892–918.

Published

2023-11-22

How to Cite

1.
Souza PHL, Corrêa JCF, Uehara L, Kishima LK, Bertolini BR, Segheto W, et al. Association between diabetes mellitus and evolution to intubation or death for individuals hospitalized with Covid-19 . Cons. Saúde [Internet]. 2023 Nov. 22 [cited 2024 Dec. 22];22(1):e24273. Available from: https://periodicos.uninove.br/saude/article/view/24273

Issue

Section

Artigos