Impacto do treinamento físico no perfil inflamatório e redox renal no desenvolvimento de síndrome metabólica

Autores

DOI:

https://doi.org/10.5585/22.2023.23408

Palavras-chave:

Síndrome metabólica, Modelos animais, Estresse oxidativo, Hipertensão, Exercício físico

Resumo

Objetivo: Investigar o efeito do treinamento físico aeróbio (TF) no perfil inflamatório e de estresse oxidativo renal em modelo experimental de desenvolvimento de síndrome metabólica (SM).
Métodos: Ratos Wistar e espontaneamente hipertensos (SHR) distribuídos nos grupos: controle (C), hipertenso (H), hipertenso frutose (HF) e hipertenso frutose treinado (HFT). Os grupos HF e HFT foram submetidos à sobrecarga de frutose (10%, 60 dias) desde o desmame. O TF foi realizado em esteira por 60 dias (5dias/semana, 40-60% velocidade máxima do teste de esforço).
Resultados: O TF promoveu redução de ânion superóxido, peróxido de hidrogênio e proteínas oxidadas comparado ao grupo HF. Além disso, o grupo HFT apresentou aumento de FRAP e nitritos comparado aos grupos H e HF. No perfil inflamatório, o TF proporcionou aumento de IL-10 e redução da razão TNFα/IL-10.
Conclusão: Os resultados demostraram que o treinamento aeróbio atenuou o estresse oxidativo e favoreceu um perfil anti-inflamatório no tecido renal em um modelo de desenvolvimento de SM.

 

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Publicado

01.06.2023

Como Citar

1.
Viana do Nascimento Filho A, Gomes Gurgel G, Thomazetti D, Petrica Neves P, Rascio Henriques Dutra M, Plens Shecaira T, et al. Impacto do treinamento físico no perfil inflamatório e redox renal no desenvolvimento de síndrome metabólica. Cons. Saúde [Internet]. 1º de junho de 2023 [citado 15º de junho de 2024];22(1):e23408. Disponível em: https://periodicos.uninove.br/saude/article/view/23408

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