Impacto do treinamento físico no perfil inflamatório e redox renal no desenvolvimento de síndrome metabólica

Antonio Viana do Nascimento Filho; Glaucivan Gomes Gurgel; Douglas Thomazetti; Pietra Petrica Neves; Marina Rascio Henriques Dutra; Tânia Plens Shecaira; Danielle da Silva Dias; Nathalia Bernardes; Kátia De Angelis

doi:10.5585/22.2023.23408

Autores

Antonio Viana do Nascimento Filho Universidade Nove de Julho (UNINOVE) https://orcid.org/0000-0003-4995-0923
Glaucivan Gomes Gurgel Universidade Nove de Julho (UNINOVE) https://orcid.org/0000-0003-2252-7789
Douglas Thomazetti Universidade Nove de Julho (UNINOVE) https://orcid.org/0000-0002-9588-7200
Pietra Petrica Neves Universidade Nove de Julho (UNINOVE) https://orcid.org/0000-0003-3834-3271
Marina Rascio Henriques Dutra Universidade Nove de Julho (UNINOVE) https://orcid.org/0000-0002-6051-6493
Tânia Plens Shecaira Universidade Federal de São Paulo (UNIFESP) https://orcid.org/0000-0002-2362-7020
Danielle da Silva Dias Universidade Federal de São Paulo (UNIFESP) https://orcid.org/0000-0003-4152-0849
Nathalia Bernardes Universidade São Judas Tadeu (USJT). https://orcid.org/0000-0001-9555-4134
Kátia De Angelis Universidade Nove de Julho, (UNINOVE) https://orcid.org/0000-0002-3640-9049

DOI:

https://doi.org/10.5585/22.2023.23408

Palavras-chave:

Síndrome metabólica, Modelos animais, Estresse oxidativo, Hipertensão, Exercício físico

Resumo

Objetivo: Investigar o efeito do treinamento físico aeróbio (TF) no perfil inflamatório e de estresse oxidativo renal em modelo experimental de desenvolvimento de síndrome metabólica (SM).
Métodos: Ratos Wistar e espontaneamente hipertensos (SHR) distribuídos nos grupos: controle (C), hipertenso (H), hipertenso frutose (HF) e hipertenso frutose treinado (HFT). Os grupos HF e HFT foram submetidos à sobrecarga de frutose (10%, 60 dias) desde o desmame. O TF foi realizado em esteira por 60 dias (5dias/semana, 40-60% velocidade máxima do teste de esforço).
Resultados: O TF promoveu redução de ânion superóxido, peróxido de hidrogênio e proteínas oxidadas comparado ao grupo HF. Além disso, o grupo HFT apresentou aumento de FRAP e nitritos comparado aos grupos H e HF. No perfil inflamatório, o TF proporcionou aumento de IL-10 e redução da razão TNFα/IL-10.
Conclusão: Os resultados demostraram que o treinamento aeróbio atenuou o estresse oxidativo e favoreceu um perfil anti-inflamatório no tecido renal em um modelo de desenvolvimento de SM.

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