Impacto do treinamento físico no perfil inflamatório e redox renal no desenvolvimento de síndrome metabólica

Antonio Viana do Nascimento Filho; Glaucivan Gomes Gurgel; Douglas Thomazetti; Pietra Petrica Neves; Marina Rascio Henriques Dutra; Tânia Plens Shecaira; Danielle da Silva Dias; Nathalia Bernardes; Kátia De Angelis

doi:10.5585/22.2023.23408

Authors

Antonio Viana do Nascimento Filho Universidade Nove de Julho (UNINOVE) https://orcid.org/0000-0003-4995-0923
Glaucivan Gomes Gurgel Universidade Nove de Julho (UNINOVE) https://orcid.org/0000-0003-2252-7789
Douglas Thomazetti Universidade Nove de Julho (UNINOVE) https://orcid.org/0000-0002-9588-7200
Pietra Petrica Neves Universidade Nove de Julho (UNINOVE) https://orcid.org/0000-0003-3834-3271
Marina Rascio Henriques Dutra Universidade Nove de Julho (UNINOVE) https://orcid.org/0000-0002-6051-6493
Tânia Plens Shecaira Universidade Federal de São Paulo (UNIFESP) https://orcid.org/0000-0002-2362-7020
Danielle da Silva Dias Universidade Federal de São Paulo (UNIFESP) https://orcid.org/0000-0003-4152-0849
Nathalia Bernardes Universidade São Judas Tadeu (USJT). https://orcid.org/0000-0001-9555-4134
Kátia De Angelis Universidade Nove de Julho, (UNINOVE) https://orcid.org/0000-0002-3640-9049

DOI:

https://doi.org/10.5585/22.2023.23408

Keywords:

Metabolic syndrome, Animal models, Oxidative stress, Hypertension, Renal tissue, Physical exercise

Abstract

Objective: To investigate the effect of aerobic exercise training (ET) on renal inflammatory and oxidative stress profiles in an experimental model of metabolic syndrome (MS) development.
Methods: Wistar and spontaneously hypertensive (SHR) rats were distributed into control (C), hypertensive (H), hypertensive fructose (HF) and trained hypertensive fructose (THF) groups. The HF and THF groups were submitted to fructose overload (10%, 60 days) since weaning. The ET was performed on a treadmill for 60 days (5 days/week, 40-60% maximum speed of the exercise test).
Results: The ET promoted reduction in renal superoxide anion, hydrogen peroxide and oxidized proteins compared to the HF group. In addition, the THF group showed an increase in FRAP and in nitrites compared to the H and HF groups. In the inflammatory profile, ET provided an increase in IL-10 and a reduction in TNFα/IL-10 ratio.
Conclusion: The results showed that aerobic training attenuated oxidative stress and favored an anti-inflammatory profile in renal tissue in a model of MS development.

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