Impact of exercise training on inflammatory and redox renal profiles in metabolic syndrome development
DOI:
https://doi.org/10.5585/22.2023.23408Keywords:
Metabolic syndrome, Animal models, Oxidative stress, Hypertension, Renal tissue, Physical exerciseAbstract
Objective: To investigate the effect of aerobic exercise training (ET) on renal inflammatory and oxidative stress profiles in an experimental model of metabolic syndrome (MS) development.
Methods: Wistar and spontaneously hypertensive (SHR) rats were distributed into control (C), hypertensive (H), hypertensive fructose (HF) and trained hypertensive fructose (THF) groups. The HF and THF groups were submitted to fructose overload (10%, 60 days) since weaning. The ET was performed on a treadmill for 60 days (5 days/week, 40-60% maximum speed of the exercise test).
Results: The ET promoted reduction in renal superoxide anion, hydrogen peroxide and oxidized proteins compared to the HF group. In addition, the THF group showed an increase in FRAP and in nitrites compared to the H and HF groups. In the inflammatory profile, ET provided an increase in IL-10 and a reduction in TNFα/IL-10 ratio.
Conclusion: The results showed that aerobic training attenuated oxidative stress and favored an anti-inflammatory profile in renal tissue in a model of MS development.
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