Pre clinical trials in rats treated with 1,3-diestearil-2-oleil-glicerol (TG1) constituent isolated from Platonia insignis
DOI:
https://doi.org/10.5585/conssaude.v14n4.5658Keywords:
Biochemistry, Acute toxicity, Platonia insignis, Phytotherapy.Abstract
Introduction: The aim of this study was to assess the acute toxicity of 1,3-distearoyl-2-oleoylglycerol (TG1), a compound isolated from Platonia insignis Mart. (bacurizeiro). Methods: The acute toxicity was analyzed by biochemical and hematological parameters. The cytotoxic study was conducted by the MTT method. The histopathological study was conducted in brain and liver tissues. Results: Acute treatment with TG1 (dose of 30 mg. kg-1) did not change the general behavior pattern of rats and not result in hematological and histological changes in the liver. The reduced levels of transaminase and alkaline phosphatase (ALKP) enzymes may suggest even certain liver protection. The biochemical analyzes demonstrated low levels of aspartate aminotransferase, ALKP and uric acid, providing preservation of kidneys and livers of animals (p<0.05). TG1 this study did not reveal cytotoxic potential by MTT method. Conclusion: These results indicate that treatment with TG1 not produce hematological, biochemical and histopathological alterations in rats suggesting low toxicity.Downloads
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Published
2016-04-27
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1.
Feitosa CM, Santos PRP dos, Freitas RM de, Rodrigues AMX, Oliveira de GAL, Costa Junior JS da, et al. Pre clinical trials in rats treated with 1,3-diestearil-2-oleil-glicerol (TG1) constituent isolated from Platonia insignis. Cons. Saúde [Internet]. 2016 Apr. 27 [cited 2024 Dec. 22];14(4):555-67. Available from: https://periodicos.uninove.br/saude/article/view/5658
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